表1 鐵死亡的誘導劑與抑制劑[1~4]

1、自噬通過鐵蛋白降解調控鐵死亡

鐵死亡最近被描述為一種自噬性細胞死亡過程，自噬通過調節細胞內鐵穩態和活性氧產生，在誘導鐵死亡發生過程中發揮核心作用[5]。

2、鐵死亡調控因子被轉運至溶酶體中，并通過自噬過程執行其功能

Keap-NRF2信號通路可能是鐵死亡與自噬之間的重要聯系[6-7]。RNA結合蛋白ELAVL1/HuR在調節肝纖維化鐵死亡中起到重要作用[8]，鐵死亡誘導劑通過抑制泛素蛋白酶體途徑提高ELAVL1蛋白水平，同時下調ELAVL1蛋白能促進自噬體產生。Beclin-1通過與SLC7A11直接相互作用，誘導脂質過氧化并通過阻斷System Xc-的活性來促進鐵死亡[9]。p53激活抑制mTOR活性，隨后促進自噬發生[10]；最近還發現核p53以轉錄依賴的方式刺激鐵死亡，通過抑制編碼System Xc-的基因SLC7A11的表達，抑制胱氨酸攝取和細胞對鐵死亡的敏感性。

Fig. 4[4] 鐵死亡與自噬的交互作用示意圖  A：鐵死亡與自噬交互作用的總體機制 B：p53在鐵死亡與自噬交互作用中的作用 C：Beclin-1在鐵死亡與自噬交互作用中的作用 D：在鐵死亡與自噬交互作用當中涉及到的其他關鍵分子和通路

3、癌癥耐藥中細胞自噬與鐵死亡的相互關系

Fig. 5[4]  自噬與鐵死亡在耐藥中微調轉換

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