A model of focal cortical injury caused by hypothermia
Traumatic brain injury and its outcomes are the main causes of disability or death worldwide. Traumatic brain injury includes primary irreversible injury and multiple secondary injuries, leading to tissue degeneration and nerve damage. Due to early damage to the blood-brain barrier, frozen cortical injury leads to vascular edema, brain swelling, and inflammation. The histopathological characteristics of low-temperature cortical injury have many iconic features of human traumatic brain injury.
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